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Updated: Apr 16, 2026

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
Published on: May 12, 2020
Oxidative stress and psychological functioning among medical students
Rani Srivastava1, Jyoti Batra2
1Professor & Head, Department of Clinical Psychology, Santosh Medical College, Ghaziabad, Uttar Pradesh, India.
Medical students experience oxidative stress linked to psychological distress. Third-year students showed higher stress levels, impacting mental health and highlighting the need for support.
Area of Science:
- Behavioral Medicine
- Psychoneuroimmunology
- Biomarkers of Stress
Background:
- Oxidative stress is increasingly recognized in behavioral medicine.
- It is associated with psychological disturbances and their outcomes.
- Malondialdehyde (MDA) is a key biomarker for oxidative stress.
Purpose of the Study:
- To assess oxidative stress (MDA levels) in medical/paramedical students.
- To investigate the relationship between oxidative stress and psychological factors.
- To compare these factors between first-year and third-year students.
Main Methods:
- 150 medical/paramedical students (75 first-year, 75 third-year) participated.
- Malondialdehyde (MDA) levels were measured to assess oxidative stress.
- Psychological variables including personality, anxiety, stress, and depression were evaluated.
Main Results:
- Both first-year and third-year students exhibited oxidative stress.
- Psychological variables correlated with oxidative stress levels, indicating vulnerability.
- Third-year students reported significantly higher stress levels.
Conclusions:
- Elevated stress in third-year students adversely affects psychological parameters.
- Medical and paramedical students are susceptible to oxidative stress and psychological distress.
- There is a need for targeted mental health interventions for these students.
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