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Left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy - a cardiac magnetic resonance

Soraya El Ghannudi1, Anthony Nghiem2, Philippe Germain3

  • 1Radiology Department, University Hospital of Strasbourg, Strasbourg, France. ; Nuclear Medicine Department, University Hospital of Strasbourg, Strasbourg, France.

Clinical Medicine Insights. Cardiology
|March 20, 2015
PubMed

Insights

Left ventricular involvement in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is common, affecting over half of patients. This condition often presents with significant right ventricular abnormalities, warranting further study into its prognostic implications.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) primarily affects the right ventricle.
  • Left ventricular (LV) involvement in ARVD/C is understudied.
  • Understanding LV involvement is crucial for comprehensive ARVD/C diagnosis and management.

Purpose of the Study:

  • To determine the frequency of LV involvement in ARVD/C.
  • To describe the clinical presentation of LV involvement in ARVD/C.
  • To characterize the pattern of LV abnormalities in ARVD/C patients.

Main Methods:

  • Retrospective analysis of cardiac magnetic resonance (CMR) data from 202 patients.
  • Diagnosis of ARVD/C based on the 2010 revised task force criteria.
  • Evaluation of LV parameters including LVEDV, LVEF, LVLE, and WMAs.

Main Results:

  • 21 patients diagnosed with ARVD/C; 52.4% exhibited LV involvement (LV-ARVD/C).
  • LV abnormalities significantly correlated with right ventricular (RV) dysfunction and late gadolinium enhancement (RVLE).
  • LV late enhancement (LVLE) was strongly associated with LV WMAs, reduced LVEF, and increased LVEDV.

Conclusions:

  • Left ventricular involvement is a common finding in ARVD/C.
  • LV-ARVD/C is frequently accompanied by moderate to severe RV abnormalities.
  • The prognostic impact of LV involvement in ARVD/C requires further investigation.
Abstract

Keywords:
arrhythmogenic right ventricular dysplasiacardiac magnetic resonance imagingleft ventricleprognosis

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