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Telaprevir experience from Turkey.
Suheyla Komur1, Behice Kurtaran1, Ayse Seza Inal1
1Department of Infectious Diseases, Cukurova University, Adana, Turkey.
Hepatitis Monthly
|March 20, 2015
Summary
Telaprevir triple therapy in chronic hepatitis C patients showed promising results, with 82.1% achieving sustained virologic response, despite frequent adverse effects. This treatment is beneficial for those with prior treatment experience.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Background:
- Triple drug regimens including protease inhibitors significantly improve sustained virologic response (SVR) in chronic hepatitis C (HCV) compared to dual therapy.
- Pegylated interferon and ribavirin dual therapy has limitations, particularly for genotype 1 HCV.
Purpose of the Study:
- To evaluate the real-world effectiveness and safety of telaprevir, peginterferon, and ribavirin triple therapy in Turkish patients with chronic hepatitis C.
- To assess treatment outcomes, including SVR rates and adverse events, in a cohort of genotype 1 HCV patients.
Main Methods:
- Retrospective analysis of 28 patients with genotype 1 chronic hepatitis C treated with telaprevir, peginterferon, and ribavirin across three Turkish medical centers.
- Data collected included demographics, treatment indications, adverse events, and treatment outcomes.
Main Results:
- 25 out of 28 patients (89.2%) completed the telaprevir-based treatment.
- 20 out of 26 evaluable patients (76.9%) achieved sustained virological response (SVR).
- Common adverse events included pruritus, rash, dysgeusia, anorectal discomfort, and anemia, leading to hospitalization in 10 patients.
Conclusions:
- Telaprevir-based triple therapy demonstrates promising efficacy for treatment-experienced chronic hepatitis C patients.
- The regimen is associated with a higher incidence of adverse events, necessitating careful monitoring and management.