Related Experiment Video
Updated: Apr 16, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Vaccine hesitancy: clarifying a theoretical framework for an ambiguous notion
Patrick Peretti-Watel1, Heidi J Larson2, Jeremy K Ward3
1INSERM, UMR912 (SESSTIM), 13006, Marseille, France; Aix Marseille University, UMR_S912, IRD, 13006, Marseille, France; ORS PACA, Southeastern Health Regional Observatory, 13006, Marseille, France.
Public confidence in vaccines is declining, leading to vaccine hesitancy (VH). This study clarifies VH as a complex decision-making process influenced by societal factors and trust in health authorities, rather than a simple spectrum of attitudes.
Area of Science:
- Public Health
- Sociology
- Behavioral Science
Background:
- Public confidence in vaccines is decreasing, with "vaccine hesitancy" (VH) widely used to describe this trend.
- Existing definitions of VH are ambiguous, encompassing beliefs, attitudes, and behaviors, making it a broad and uncertain concept.
- Current understanding of VH as a linear spectrum from anti-vaccine to pro-vaccine attitudes is questioned.
Purpose of the Study:
- To review and analyze current definitions and characteristics of vaccine hesitancy (VH).
- To identify ambiguities and limitations in the conceptualization of VH.
- To propose a new theoretical framework for understanding VH as a decision-making process.
Main Methods:
- Literature review of existing definitions and characteristics of vaccine hesitancy.
- Critical analysis of the conceptual ambiguities and limitations of VH.
- Development of a theoretical framework integrating societal factors and trust in health systems.
Main Results:
- Vaccine hesitancy (VH) is defined inconsistently across public health literature, often as a catch-all category.
- VH is characterized by a heterogeneous population exhibiting reluctant conformism, vaccine-specific behaviors, or a combination thereof.
- A proposed framework views VH as a decision-making process influenced by "healthism/risk culture" and confidence in health authorities and medicine.
Conclusions:
- Vaccine hesitancy (VH) is an ambiguous concept lacking a clear theoretical foundation.
- The prevailing understanding of VH as a simple continuum is insufficient.
- A novel framework positions VH as a complex decision-making process influenced by societal values and trust in healthcare.
Related Concept Videos
Vaccinations
Vaccines
Models of Health Promotion and Illness Prevention I
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
Bias in Epidemiological Studies
Vaccine Production
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

