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Highlights in pathogenesis of vitiligo
Ghada F Mohammed1, Amal Ha Gomaa1, Mohammed Saleh Al-Dhubaibi1
1Ghada F Mohammed, Amal HA Gomaa, Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University, Ismailia 41551, Egypt.
World Journal of Clinical Cases
|March 20, 2015
Summary
Vitiligo pathogenesis remains unclear despite extensive research. This review explores various theories, including genetics, autoimmunity, and oxidative stress, highlighting its multifactorial nature for better treatment development.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Vitiligo is a prevalent pigmentary disorder with significant psychological impact.
- The exact pathogenesis of vitiligo has remained elusive despite decades of research worldwide.
Purpose of the Study:
- To review and present updated theories on the pathogenesis of vitiligo.
- To consolidate current understanding of the multifactorial nature of this condition.
Main Methods:
- Comprehensive literature review of established and emerging vitiligo pathogenesis theories.
- Synthesis of findings from genetic, neural, autoimmune, and biochemical perspectives.
Main Results:
- Discussed theories include genetic predisposition, neural, autoimmune, reactive oxygen species, zinc-α2-glycoprotein deficiency, viral, and intrinsic factors.
- Highlighted biochemical, molecular, and cellular alterations leading to melanocyte dysfunction.
- Emphasized vitiligo as a multifactorial disease with interacting contributing factors.
Conclusions:
- Vitiligo pathogenesis is complex and involves the interplay of multiple factors.
- Further research is crucial to elucidate these interactions for improved therapeutic strategies.
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