Asthma and metabolic syndrome: Current knowledge and future perspectives
Laura Serafino-Agrusa1, Mario Spatafora1, Nicola Scichilone1
1Laura Serafino-Agrusa, Mario Spatafora, Nicola Scichilone, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, 90146 Palermo, Italy.
World Journal of Clinical Cases
|March 20, 2015
Summary
Asthma and metabolic syndrome share links beyond body mass. Weight reduction improves asthma, suggesting a bidirectional relationship needing further study.
Area of Science:
- Pulmonary Medicine
- Metabolic Disorders
- Immunology
Background:
- Asthma and obesity share epidemiological links, extending to metabolic syndrome markers like insulin resistance and dyslipidemia.
- Obesity is a risk factor for asthma onset in children and adults, potentially complicating asthma control and treatment.
- Existing Th2 inflammation or atopy theories don't fully explain the asthma-obesity link; metabolic factors like hyperglycemia, hyperinsulinemia, and dyslipidemia are implicated.
Purpose of the Study:
- To review current knowledge on the association between metabolic syndrome and asthma.
- To explore potential pathogenetic mechanisms linking these conditions.
- To identify future research directions and strategic approaches.
Main Methods:
- Literature review of epidemiological and mechanistic studies.
- Analysis of clinical data demonstrating asthma symptom improvement post-weight reduction.
- Exploration of bidirectional interactions between asthma and metabolic syndrome components.
Main Results:
- The association between asthma and metabolic syndrome is complex and not solely explained by body mass.
- Weight reduction positively impacts asthma symptoms, indicating a causal link.
- Metabolic syndrome components may directly influence asthma pathophysiology.
Conclusions:
- The relationship between asthma and metabolic syndrome is bidirectional and involves complex interactions.
- Metabolic dysregulation, beyond obesity, plays a significant role in asthma.
- Further research is needed to elucidate specific mechanisms and develop targeted therapeutic strategies.
More Related Videos
Related Concept Videos
01:20Asthma: Pathogenesis and Management
1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K
01:26Asthma-II: Pathophysiology and Classification
5.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
5.0K
01:29Asthma-I: Introduction
3.8K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.8K
01:24Asthma-III: Symptoms and Complications
3.7K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.7K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.4K
01:30Asthma-IV: Diagnostic and Management
3.4K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.4K