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Evaluation of functional, autonomic and inflammatory outcomes in children with asthma

Evelim Leal de Freitas Dantas Gomes1, Dirceu Costa1

  • 1Evelim Leal de Freitas Dantas Gomes, Rehabilitation Sciences, Physical Therapy Course, University Nove de Julho, São Paulo 01504-001, Brazil.

World Journal of Clinical Cases
|March 20, 2015
PubMed

Insights

Childhood asthma involves airway inflammation and autonomic dysfunction. Non-pharmacological therapies aim to improve clinical control and reduce airway obstruction, enhancing functional capacity in affected children.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Immunology

Background:

  • Childhood asthma is a prevalent respiratory condition marked by persistent airway inflammation.
  • Chronic inflammation stems from imbalances in pro- and anti-inflammatory pathways and autonomic dysfunction.
  • These factors contribute to sedentary lifestyles, impacting functional capacity and disease management.

Purpose of the Study:

  • To review key neural, inflammatory, and functional mechanisms influencing pediatric asthma.
  • To highlight the role of these mechanisms in disease pathogenesis and control.
  • To discuss non-pharmacological therapeutic targets for asthma management.

Main Methods:

  • Literature review focusing on neural, inflammatory, and functional aspects of childhood asthma.
  • Analysis of mechanisms contributing to airway inflammation and autonomic dysfunction.
  • Examination of the impact of lifestyle on asthma control and functional capacity.

Main Results:

  • Identified critical neural and inflammatory pathways central to asthma development in children.
  • Highlighted the significant role of autonomic dysfunction in asthma pathogenesis.
  • Emphasized the link between sedentary behavior and reduced functional capacity in pediatric asthma patients.

Conclusions:

  • Understanding these mechanisms is crucial for effective asthma management in children.
  • Non-pharmacological interventions, including non-invasive ventilation, can aid in controlling airway obstruction and hyperinflation.
  • Addressing neural, inflammatory, and functional factors offers a comprehensive approach to improving clinical outcomes in childhood asthma.

Keywords:
AsthmaAutonomic nervous systemChildContinuous positive airway pressureEvaluationFunctional capacityInflammatory mechanismsNoninvasive ventilation

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