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Altered interhemispheric functional coordination in chronic tinnitus patients.

Yu-Chen Chen1, Wenqing Xia2, Yuan Feng3

  • 1Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China ; Center for Hearing and Deafness, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.

Biomed Research International
|March 20, 2015
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Summary

This study reveals altered brain connectivity in chronic tinnitus patients, specifically in regions like the middle temporal gyrus. These changes in interhemispheric functional connectivity correlate with tinnitus duration and distress.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Audiology

Background:

  • Tinnitus may involve abnormal brain structure and communication between hemispheres.
  • Interhemispheric interaction is crucial for brain function.

Purpose of the Study:

  • To investigate interhemispheric functional connectivity using voxel-mirrored homotopic connectivity (VMHC).
  • To explore the relationship between VMHC and clinical features in chronic tinnitus.

Main Methods:

  • Resting-state fMRI scans were acquired from 28 chronic tinnitus patients and 30 healthy controls.
  • Voxel-mirrored homotopic connectivity (VMHC) was computed to assess functional coordination between homologous brain regions.

Main Results:

  • Tinnitus patients exhibited increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus compared to controls.
  • A positive correlation was observed between tinnitus duration and VMHC in the uncus.
  • VMHC alterations in specific brain areas correlated with tinnitus distress.

Conclusions:

  • Chronic tinnitus is associated with altered interhemispheric functional connectivity.
  • These connectivity changes may play a role in the neuropathophysiology of tinnitus.
  • VMHC is a promising method for understanding tinnitus-related brain alterations.