AKAP5 signaling complexes: focal points and functional properties
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Updated: Apr 16, 2026

Real-time Live Imaging of T-cell Signaling Complex Formation
Published on: June 23, 2013
Yanjing Guo1, Tao Bo2, Xinli Zhou1
1Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
Objective:
Kinase Anchoring Proteins (AKAPs) have evolved to regulate the spatial and temporal organization of cellular signal transduction. As a typical member, AKAP5 which consisting of three orthologues: bovine AKAP75, rodent AKAP150 and human AKAP79, is the best known model in the anchoring and targeting properties. It is shown that AKAP5 can bind β2-adrenergic receptor, which is a member of GPCR superfamily, and orchestrate the interactions of various protein kinases, protein phosphatases and cytoskeletal element. AKAP5 is originally identified as a component of the postsynaptic density in neurons and plays a vital role in modulating neuronal activities. Subsequently, the AKAP5 complexes are also detected in other tissues and participated in various processes.
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