Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Brainstem

Brainstem

The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The economic burden of dementia in Europe: COIN-Eu dementia.

Journal of Alzheimer's disease : JAD·2026

Same author

Hippocampal-cortical structural networks in the progression of cognitive impairment: A source-based morphometry analysis in individuals with subjective cognitive decline, mild cognitive impairment and Alzheimer's disease.

Neurobiology of aging·2026

Same author

Shaping the cognitive reserve: the role of lifelong enrichment and education in the Alzheimer's disease continuum.

Frontiers in aging neuroscience·2026

Same author

Treatment of chronic insomnia in elderly adults with dual orexin receptor antagonists: A systematic review and meta-analysis.

Sleep·2026

Same author

Adherence to the Mediterranean diet and all-cause mortality: A systematic review and meta-analysis within the Italian National Guidelines "La Dieta Mediterranea".

Nutrition (Burbank, Los Angeles County, Calif.)·2026

Same author

Deregulation of Synaptic Plasticity-Related MicroRNAs After Repetitive Transcranial Magnetic Stimulation in Alzheimer's Disease.

Molecular neurobiology·2026

Search research articles

Related Experiment Video

Updated: Apr 16, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

Iron and Parkinson's disease.

Francesco Di Lorenzo¹

¹"Ambulatorio Privato di Scienze Mediche", Valenzano, Bari, Italy.

Neuro Endocrinology Letters

|March 20, 2015

Summary

Chelation therapy targeting iron may improve Parkinson's disease symptoms. Further research into iron metabolism in neurodegeneration is crucial for developing new treatments.

Area of Science:

Neuroscience
Clinical Medicine
Biochemistry

Background:

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms.
Iron accumulation and associated oxidative stress are implicated in PD pathogenesis.
Current treatments for PD primarily manage symptoms but do not halt disease progression.

Observation:

A case study involving a Parkinson's disease patient treated with chelation therapy aimed at reducing iron levels.
The therapy was administered without direct correlation to baseline serum iron levels.
The patient experienced improvements in both motor and non-motor symptoms.

Findings:

The patient's condition, evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS) III score, showed significant improvement post-chelation therapy.

More Related Videos

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Related Experiment Videos

Last Updated: Apr 16, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

This suggests a potential therapeutic benefit of targeting iron dysregulation in Parkinson's disease.

The study highlights the need for further investigation into the role of iron metabolism in neurodegeneration.

Implications:

Iron-dependent oxidative stress modulation could offer a novel therapeutic strategy for Parkinson's disease.
Understanding iron metabolism in neurodegenerative conditions is critical for future treatment development.
This case presentation warrants larger clinical trials to validate chelation therapy's efficacy and safety in PD.