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Red and NIR light dosimetry in the human deep brain.

A Pitzschke1, B Lovisa, O Seydoux

  • 1Federal Institute of Technology (EPFL), Institute of Chemical Sciences and Engineering (ISIC), 1015 Lausanne, Switzerland.

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|March 20, 2015
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Summary

Photobiomodulation (PBM) shows promise for Parkinson's Disease (PD). This study optimized light delivery to deep brain tissues, finding 808 nm and novel routes like the sphenoid sinus significantly improve efficiency for potential PD therapies.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Photomedicine

Background:

  • Parkinson's Disease (PD) is a neurodegenerative disorder.
  • Photobiomodulation (PBM) is being investigated as a potential therapeutic approach for PD.
  • Effective delivery of light to deep brain structures is crucial for PBM efficacy.

Purpose of the Study:

  • To measure and model light propagation in deep brain tissues for transcranial and transsphenoidal illumination.
  • To optimize optical parameters for enhanced light delivery to brain regions relevant to PD.
  • To evaluate different illumination routes for improved PBM therapy in PD.

Main Methods:

  • Monte Carlo simulations were used to model optical parameters of human brain tissue.
  • Light propagation was measured in a cadaver head using transcranial and transsphenoidal illumination at 671 nm and 808 nm.
  • A high-resolution voxel mesh of the skull was created to represent different tissue types.

Main Results:

  • The 808 nm wavelength demonstrated better light delivery to deep brain tissues compared to 671 nm.
  • Optimized optical parameters improved the accuracy of simulated light distribution.
  • Ventricular illumination achieved a 20-fold higher efficiency for deep brain light delivery compared to transcranial methods.

Conclusions:

  • Transcranial and transsphenoidal illumination are feasible for delivering light to deep brain tissues.
  • Novel application routes, including the sphenoid sinus, combined with optimized parameters, enhance PBM efficiency for PD treatment.
  • This research opens new therapeutic avenues for PD and other neurological conditions treatable with light therapy.