Comparison of doxorubicin anticancer drug loading on different metal oxide nanoparticles
Khalid Rashid Javed1, Munir Ahmad, Salamat Ali
1From the Department of Physics (KR, SA, MZB, MN, ARB), Government College University (GCU); Pakistan Council for Scientific and Industrial Research (PCSIR) (KR); Department of Medical Physics (MA, AS), Institute of Nuclear Medicine and Oncology (INMOL); Department of Physics (MA), The University of Lahore, Lahore, Pakistan; and Department of Physics (MN), Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
Abstract:
Nanomaterials are being vigorously investigated for their use in anticancer drug delivery regimes or as biomarkers agents and are considered to be a candidate to provide a way to combat severe weaknesses of anticancer drug pharmacokinetics, such as their nonspecificity. Because of this weakness, a bigger proportion of the drug-loaded nanomaterials flow toward healthy tissues and result in undesirable side effects. It is very important to evaluate drug loading and release efficiency of various nanomaterials to find out true pharmacokinetics of these drugs.This observational study aims to evaluate various surface functionalized and naked nanomaterials for their drug loading capability and consequently strengthens the Reporting of Observational Studies in Epidemiology (STROBE). We analyzed naked and coated nanoparticles of transition metal oxides for their further loading with doxorubicin, a representative water-soluble anticancer drug.Various uncoated and polyethylene glycol-coated metal oxide nanoparticles were synthesized and loaded with anticancer drug using simple stirring of the nanoparticles in a saturated aqueous solution of the drug. Results showed that surface-coated nanoparticles have higher drug-loading capabilities; however, certain naked metal oxide nanoparticles, such as cobalt oxide nanoparticles, can load a sufficient amount of drug.
