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Updated: Apr 16, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
Published on: June 25, 2018
Controlled synthesis of phosphorylcholine derivatives of poly(serine) and poly(homoserine)
Ilya Yakovlev1, Timothy J Deming1
1†Department of Chemistry and Biochemistry and ‡Department of Bioengineering, University of California, Los Angeles, California 90095, United States.
Abstract:
We report methods for the synthesis of polypeptides that are fully functionalized with desirable phosphorylcholine, PC, groups. Because of the inherent challenges in the direct incorporation of the PC group into α-amino acid N-carboxyanhydride (NCA) monomers, we developed a synthetic approach that combined functional NCA polymerization with efficient postpolymerization modification. While poly(L-phosphorylcholine serine) was found to be unstable upon synthesis, we successfully prepared poly(L-phosphorylcholine homoserine) with controlled chain lengths and found these to be water-soluble with disordered chain conformations.
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