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Chiroptical study and absolute configuration of securinine oxidation products
Egor Chirkin1, William Atkatlian, Quyên Do
1a Laboratoire de Pharmacognosie UMR CNRS 8638 COMETE, Faculté de Pharmacie, Université Paris Descartes , 4 Avenue de l'Observatoire, F-75006 Paris , France.
Abstract:
Time-dependant density functional theory-electronic circular dichroism spectra prediction was carried out to study the absolute configuration of phyllanthidine-type derivatives 5 and 6, derived from securinine (1) and its enantiomer virosecurinine (2), respectively. This method demonstrated to be very reliable in this alkaloid series. Thus, 5 and 6 shared the same stereochemistry as their parent precursors, confirming the retentive nature of the oxidation sequence. In addition, this study highlighted the key role of the methylene bridge (BC ring) in the chiroptical activity of these compounds. These results fully clarified the stereochemical relationships between the phyllanthidine and the securinine subgroups.
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