A case of mania secondary to propafenone

A case of mania secondary to the administration of a new antiarrhythmic, propafenone, is described. This is a previously unrecognized potential complication in the use of this agent. Since propafenone is chemically related to a new antidepressant, bupropion, it may possess some antidepressant activity and thus have the potential to produce affective psychiatric side effects.