[Clinical features of persistent viral infections in women. Differential diagnostics]

To study clinical synptoims in patients with persistent viral infection (P VI).

The study included 325 women with PVI diagnosed during examination of 1119 women. 151 of them with verified diagnosis of PVI presented with pregnancy, 64 with miscarriage, 89 with premature delivery, and 29 suffered infertility. These conditions were not detected in 635, 74, 33 and 52 women respectively. A variety of clinical symptoms included pathological vaginal discharge with putrefactive odor irritation, itchy and burning genitalia, painful intercourse, menstrual disorders, dysuria, drawing pain in the lower abdomen.

Analysis of clinical data showed that vaginal discharge with putrefactive odor irritation, itchy and burning genitalia were the leading symptoms of PYVI documented in 59.4?2.7-76.9+2.3% of the examined patients. Each woman with PVI had at least 2 or 3 of these symnptoms which allows to regard them as markers of this condition. We distinguished 4 clinical forms of PVI: asymptomatic (14.5?2.0%), mild (34.8 +/- 32.1%), moderate (32.64 +/- 2.6%) and severe (18.2 +/- 2.1%). Asymptomatic form largely occurs in the patients using no antibiotics (47.7 +/- 6.2%) although the same group very frequently suffer severe PVI (34.4-6.1%). The presence of pathogenic microflora, Chlamydia and Trichomonads inr the genital tract increases the frequency of moderate and severe forms of PVI up to 23.6 +/- 4.1 and 32.2 +/- 6.1% which suggests the necessity of adequate choice and application of pharmaceuticals acting on all the above pathogens.

PVI in pregnant women and patients with reproductive pathology shows up a specific clinical picture of diagnostic significance.