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Updated: Apr 16, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Phenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and
Nimeshi Jayakody1, E Clare Harris1, David Coggon2
1MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Background:
Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited.
Sources Of Data:
We searched Medline and Embase, looking for cohort or case-control studies that provided data on risk of STS and/or NHL in relation to phenoxy herbicides, and checked the reference lists of relevant publications for papers that had been missed.
Areas Of Agreement, Areas Of Controversy:
The extensive evidence is not entirely consistent, and a hazard of STS or NHL cannot firmly be ruled out. However, if there is a hazard, then absolute risks must be small.
Growing Points, Areas Timely For Developing Research:
Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.
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