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Assessment and management of treatment-refractory obsessive-compulsive disorder in children

Michael H Bloch1, Eric A Storch2

  • 1Yale Child Study Center, Yale University, New Haven, CT.

Journal of the American Academy of Child and Adolescent Psychiatry
|March 21, 2015
PubMed

Insights

Selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) effectively treat pediatric obsessive-compulsive disorder (OCD). However, more research is needed for treatment-refractory pediatric OCD.

Area of Science:

  • Child and Adolescent Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Pediatric obsessive-compulsive disorder (OCD) presents unique challenges in treatment.
  • Treatment resistance is a significant concern in pediatric OCD cases.

Purpose of the Study:

  • To review current assessment and treatment strategies for treatment-refractory pediatric OCD.
  • To identify evidence-based interventions for pediatric OCD that does not respond to initial treatments.

Main Methods:

  • Conducted a PubMed search for controlled trials in pediatric OCD.
  • Reviewed practice guidelines for adult and child OCD treatment, focusing on refractory cases.

Main Results:

  • Selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) are effective for pediatric OCD.
  • CBT shows efficacy even in pediatric patients with refractory OCD symptoms.
  • Limited data exists on interventions like antipsychotic augmentation or glutamate modulators in pediatric populations.

Conclusions:

  • Pharmacological options are available for pediatric OCD, but evidence for refractory cases is scarce.
  • Further research is essential to guide treatment decisions for challenging pediatric OCD patients.
  • The efficacy and side effect profiles of interventions for treatment-refractory pediatric OCD require further investigation.
Abstract

Keywords:
antipsychotic agentscognitive-behavioral therapyobsessive-compulsive disorderserotonin uptake inhibitorssystematic review

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