Related Experiment Video
Updated: Apr 16, 2026

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
Published on: December 16, 2022
Robustness of steady state recycling chromatography with an integrated solvent removal unit
Jani Siitonen1, Mika Mänttäri1, Andreas Seidel-Morgenstern2
1Lappeenranta University of Technology, Skinnarilankatu 34, FI-53850 Lappeenranta, Finland.
Abstract:
The robustness of a hybrid separation process where the performance of mixed-recycle steady state recycling chromatography is enhanced by integrating it with a solvent removal unit is analysed theoretically and by means of numerical simulations. The equilibrium theory of chromatography is applied to derive equations for boundaries of feasible operating parameters in such a hybrid process. Visualization of the feasible operating parameter ranges helps in analysing the influence of various physical and process parameters of robustness of an operating point. It is observed that process robustness can be improved by adjusting the solvent removal capacity or the cut times. When the solvent removal capacity increases, the region of feasible cut times becomes narrower due to increased non-linearity of the system. This makes it more difficult to maintain robust operation.
Related Concept Videos
High-Performance Liquid Chromatography: Elution Process
Optimizing Chromatographic Separations
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
Recrystallization: Solid–Solution Equilibria
Principles Of Column Chromatography
Supercritical Fluid Chromatography
SFC utilizes a supercritical fluid mobile phase,...
Chromatography: Introduction
The phase in which the compounds linger or on which the compounds adsorb is called the stationary phase, whereas the mobile phase is the solvent that carries the solutes to be analyzed. In traditional column chromatography, the mixture flows through the stationary phase, and the compounds partition between the stationary and mobile phases...

