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Functional competition within a membrane: Lipid recognition vs. transmembrane helix oligomerization.

Michael Stangl1, Dirk Schneider1

  • 1Department of Pharmacy and Biochemistry, Johannes-Gutenberg-University Mainz, Johann-Joachim-Becher-Weg 30, 55128 Mainz, Germany.

Biochimica Et Biophysica Acta
|March 21, 2015
PubMed
Summary

Lipids can bind to single-span membrane proteins, influencing their stability and activity. This interaction, particularly with transmembrane helices, may regulate protein function and signaling pathways.

Keywords:
C99Lipid bindingMembrane proteinOligomerizationSyntaxin 1Ap24

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