Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Seizures: Classification01:13

Seizures: Classification

2.4K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure-Guided Prioritization and Synthesis of New Ligands for GPR17 Receptor.

ACS omega·2026
Same author

Mechanical Thrombectomy in Patients With Cervical Artery Dissection: A Multicenter Analysis on Technical, Safety, and Functional Outcomes.

European journal of neurology·2026
Same author

Use of High-Efficacy Therapy in Children With Multiple Sclerosis to Prevent Long-Term Disability.

Neurology·2026
Same author

The cytokine signature in multiple sclerosis: a study during the SARS-CoV-2 pandemic.

Frontiers in immunology·2026
Same author

EDSS and disease duration associate with progression independent of relapse and MRI activity in natalizumab-treated multiple sclerosis patients.

Multiple sclerosis and related disorders·2026
Same author

Duropathies as Unifying Concept-Part Two: A Narrative Overview of Clinical and Neuroradiological Features.

Neurology international·2026
Same journal

Impact of multiple sclerosis disease-modifying therapies on chronic lesion tissue expansion.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Tobacco smoking disrupts bile acid and tryptophan metabolism in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Missed radiologic disease activity by conventional side-by-side MRI comparison is associated with future disease activity in multiple sclerosis: Adopting semiautomated coregistration-fusion into clinical practice.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Longitudinal magnetic resonance spectroscopy study of metabolite changes over 2 years in relapsing and primary progressive multiple sclerosis treated with ocrelizumab.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Racial identity, marginalization, and depression in pediatric-onset multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Disability and race in MS: Does socioeconomic disadvantage play a role?

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.4K

Cortical relapses in multiple sclerosis.

Marco Puthenparampil1, Davide Poggiali2, Francesco Causin3

  • 1Department of Neurosciences NPSRR, Multiple Sclerosis Centre Veneto Region, First Neurology Clinic, University of Padova, Italy marco.puthenparampil@studenti.unipd.it.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 21, 2015
PubMed
Summary
This summary is machine-generated.

Cortical lesions in multiple sclerosis (MS) can cause acute relapses with distinct neurological symptoms. Advanced MRI techniques are crucial for detecting these lesions and understanding MS progression.

Keywords:
Case studycortical lesionsgrey matterinversion recoverymagnetic resonance imagingmultiple sclerosisrelapserelapse symptomsrelapsing–remitting multiple sclerosis

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.2K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.2K

Related Experiment Videos

Last Updated: Apr 16, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.4K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.2K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.2K

Area of Science:

  • Neurology
  • Neuroimmunology
  • Neuroimaging

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) disease affecting white and grey matter.
  • Cortical damage in MS contributes to physical and cognitive disability.
  • The link between cortical lesions and clinical relapses in MS was previously undescribed.

Observation:

  • Five relapsing-remitting MS (RRMS) patients experienced acute relapses.
  • These relapses were associated with the sudden appearance of large, inflammatory cortical lesions.
  • Symptoms included aphasia, agraphia, limb weakness, hypertonia, and seizures.

Findings:

  • Cortical lesions can manifest as acute neurological events in MS.
  • Specific MRI sequences like DIR and PSIR are vital for visualizing cortical lesions.
  • The study highlights the clinical significance of cortical pathology in MS.

Implications:

  • Cortical relapses are a recognized phenomenon in MS.
  • Enhanced MRI protocols are recommended for MS patients with cortical dysfunction symptoms.
  • Understanding cortical pathology is key to managing MS disability.