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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Related Experiment Video

Updated: Apr 16, 2026

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Core-shell designed scaffolds for drug delivery and tissue engineering.

Roman A Perez1, Hae-Won Kim2

  • 1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea.

Acta Biomaterialia
|March 21, 2015
PubMed
Summary

Core-shell scaffolds offer advanced drug delivery and tissue engineering solutions by precisely controlling the release of signaling molecules and stem cells for enhanced therapeutic outcomes.

Keywords:
Cell encapsulationCore-shell designDrug deliveryTherapeutic scaffoldsTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Scaffolds are crucial for drug delivery and tissue engineering, particularly for therapeutic agents like signaling molecules and stem cells.
  • Core-shell designs offer a promising strategy to spatially organize and deliver these therapeutic components.
  • Existing fabrication methods enable the creation of core-shell nano/microstructures for advanced applications.

Purpose of the Study:

  • To highlight the therapeutic potential of core-shell scaffolds in drug delivery and tissue engineering.
  • To explore the controlled and sequential release of signaling molecules and stem cells using core-shell architectures.
  • To emphasize the role of core-shell designs in creating conducive microenvironments for encapsulated cells.

Main Methods:

  • Fabrication of core-shell nano/microfibers and nano/microspheres using techniques like co-concentric nozzle extrusion, microfluidics, and chemical confinement.
  • Spatial allocation of signaling molecules and drugs within the core and/or shell compartments.
  • Encapsulation of stem cells within the core for protection and controlled release.

Main Results:

  • Core-shell scaffolds facilitate controllable and sequential delivery of therapeutic agents, optimizing treatment efficacy.
  • Encapsulated stem cells are protected within the core, enabling ex vivo culture and in vivo tissue regeneration.
  • The three-dimensional, tissue-mimicking microenvironment within scaffolds promotes cell viability and therapeutic molecule secretion.
  • Material properties, geometry, and form of core-shell scaffolds significantly influence biomolecule release and cell behavior.

Conclusions:

  • Core-shell scaffold designs are highly effective for therapeutic applications, including stem cell delivery and signaling molecule release.
  • These scaffolds show immense promise for advancing tissue regeneration and disease treatment strategies.
  • Tuning scaffold parameters offers a powerful method to optimize therapeutic delivery and cellular responses.