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Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
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Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis

Maik Drechsler1, Johan Duchene2, Oliver Soehnlein1

  • 1From the Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (M.D., J.D., O.S.); Department of Pathology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands (M.D., O.S.); and German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany (M.D., O.S.). maik.drechsler@med.uni-muenchen.de oliver.soehnlein@gmail.com.

Arteriosclerosis, Thrombosis, and Vascular Biology
|March 21, 2015
PubMed

Insights

Chemokines and their receptors control monocyte movement, which is crucial for atherosclerosis development. Understanding this interplay aids in developing treatments for this chronic inflammatory artery disease.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Inflammation Research

Background:

  • Atherosclerosis is a chronic inflammatory disease affecting large arteries.
  • It involves monocyte infiltration, macrophage accumulation, and foam cell formation.
  • Chemokines and their receptors are key regulators of immune cell trafficking.

Purpose of the Study:

  • To review the current understanding of monocyte-chemokine interactions in atherosclerosis.
  • To highlight the role of these interactions in disease development, progression, and regression.

Main Methods:

  • Literature review of studies on monocyte trafficking and chemokines in atherosclerosis.
  • Synthesis of current knowledge on chemokine receptor signaling in monocytes.
  • Analysis of the impact of chemokines on macrophage differentiation and function.

Main Results:

  • Chemokines precisely regulate monocyte recruitment to the arterial wall.
  • Specific chemokine pathways are critical at different stages of atherosclerosis.
  • Targeting chemokine pathways offers potential therapeutic strategies.

Conclusions:

  • Monocyte-chemokine axis is central to atherosclerosis pathogenesis.
  • Further research into these interactions can reveal novel therapeutic targets.
  • Modulating chemokine signaling may impact atherosclerosis progression and regression.

Keywords:
atherosclerosischemokinesmonocytes

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