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Prognostic value of microRNA-145 in patients with various cancers: a meta-analysis

Shu-Long Dai, Jin Zhou, Chao Pan

    Cancer Biomarkers : Section a of Disease Markers
    |March 21, 2015
    PubMed
    Abstract

    Insights

    Low microRNA-145 (miR-145) expression is linked to poorer overall survival in cancer patients. This finding highlights miR-145 as a potential biomarker for cancer prognosis monitoring.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biomarker Research

    Background:

    • MicroRNA-145 (miR-145) is recognized for its significant role in cancer prognosis.
    • Understanding the specific impact of miR-145 on patient survival is crucial for advancing cancer care.

    Purpose of the Study:

    • To evaluate the prognostic significance of miR-145 expression in patients across various cancer types.
    • To determine if miR-145 levels correlate with overall survival (OS) and recurrence-free survival (RFS).

    Main Methods:

    • A systematic meta-analysis was conducted, pooling data from 8 studies encompassing 615 cancer cases.
    • Literature search performed across PubMed, EMBASE, Web of Science, and Cochrane Database of Systematic Reviews.
    • Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the association between miR-145 expression and patient survival outcomes.

    Main Results:

    • Low miR-145 expression was significantly associated with poorer overall survival (HR = 1.80, 95% CI = 1.19-2.70) in a meta-analysis of multiple cancers.
    • Excluding a potentially heterogeneous study strengthened the association, indicating an increased prognostic value for low miR-145 expression (HR = 2.20, 95% CI = 1.63-1.97).
    • No significant correlation was found between miR-145 expression levels and recurrence-free survival (RFS).

    Conclusions:

    • miR-145 expression levels are significantly associated with overall survival in cancer patients.
    • Low miR-145 expression serves as a potential predictive biomarker for monitoring cancer prognosis.
    • Further research may explore therapeutic strategies targeting miR-145 to improve patient outcomes.
    Keywords:
    cancermeta-analysismicroRNA-145prognosis

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