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Increased risk of dementia among patients with pulmonary tuberculosis: a retrospective population-based cohort study
Yi-Hao Peng1, Chih-Yu Chen2, Ching-Hua Su3
1Department of Respiratory Therapy, China Medical University Hospital, Taichung, Taiwan Department of Respiratory Therapy, China Medical University, Taichung, Taiwan.
Objective:
We investigated and compared the risk of dementia development in a cohort of patients with tuberculosis (TB).
Methods:
The study involved 6473 patient with newly diagnosed TB, and each patient was randomly frequency matched with 4 people without TB based on age, sex, and index year. The risk of dementia development was analyzed using Cox proportional hazards regression.
Results:
Among the patients with TB, the overall risk of developing dementia was 1.21-fold significantly higher than the non-TB cohort. In the stratified analysis of dementia risks, only the patients with TB who were male or 50 to 64 years of age exhibited a significantly higher risk of dementia development compared with those without TB. An analysis of the follow-up duration revealed that patients with TB had a 1.78-fold increased risk within 1 year of follow-up.
Conclusion:
Patients with TB have a significantly higher risk of developing dementia than that of the general population.
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