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Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

Takashi Hitsumoto1, Kohji Shirai2

  • 1Hitsumoto Medical Clinic, Yamaguchi, Japan.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|March 21, 2015
PubMed

Insights

In Japanese metabolic syndrome patients, elevated high-sensitivity cardiac troponin T (hs-cTnT) is linked to oxidative stress and arterial dysfunction, not metabolic parameters. Age also influences hs-cTnT levels.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Biomarkers

Background:

  • High-sensitivity cardiac troponin T (hs-cTnT) is a key biomarker for heart failure and cardiovascular events.
  • The clinical significance of hs-cTnT in metabolic syndrome remains largely unexplored.
  • Understanding hs-cTnT in metabolic syndrome is crucial for risk stratification.

Purpose of the Study:

  • To investigate factors associated with elevated hs-cTnT in Japanese patients with metabolic syndrome.
  • To explore the relationship between hs-cTnT and diagnostic parameters of metabolic syndrome.
  • To identify independent predictors of hs-cTnT elevation in this population.

Main Methods:

  • A cohort of 258 middle-aged Japanese males with metabolic syndrome and no prior cardiovascular events was studied.
  • hs-cTnT levels were measured and correlated with various clinical parameters, including metabolic syndrome diagnostic criteria.
  • Multiple regression analysis was employed to identify independent predictors of hs-cTnT.

Main Results:

  • No significant correlation was found between hs-cTnT and standard metabolic syndrome diagnostic parameters.
  • hs-cTnT showed significant positive correlations with age, brain natriuretic peptide, reactive oxygen metabolites (oxidative stress marker), and cardio-ankle vascular index (arterial function marker).
  • Multiple regression confirmed age, oxidative stress, and arterial function as independent factors associated with hs-cTnT levels.

Conclusions:

  • In Japanese metabolic syndrome patients, elevated hs-cTnT is associated with in vivo oxidative stress and arterial dysfunction.
  • These findings suggest that hs-cTnT may reflect subclinical cardiovascular damage related to oxidative stress and vascular abnormalities in metabolic syndrome.
  • The study highlights the importance of assessing oxidative stress and arterial function in metabolic syndrome patients with elevated hs-cTnT.
Abstract

Keywords:
cardio–ankle vascular indexmetabolic syndromeoxidative stressrisk factortroponin

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