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Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery
1Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
The Analyst
|March 21, 2015
Abstract:
A label-free method is developed to ratiometrically determine the stoichiometry of oligonucleotides attached to the surface of gold nanoparticle (GNP) by whispering gallery mode biosensing. Utilizing this scheme, it is furthermore shown that the stoichiometric ratio of GNP attached oligonucleotide species can be controlled by varying the concentration ratio of thiolated oligonucleotides that are used to modify the GNP.
