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Updated: Apr 16, 2026
10:21
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
Published on: June 14, 2016
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Tenascins in fibrotic disorders-from bench to bedside.
M Kasprzycka1, C Hammarström, G Haraldsen
1a Department of Pathology.
Cell Adhesion & Migration
|March 21, 2015
Summary
Tenascin C plays a key role in fibrosis development and chronic inflammation. Targeting tenascin C offers potential therapeutic strategies for fibrotic diseases.
Area of Science:
- Biochemistry
- Cell Biology
- Immunology
Background:
- Fibrosis is a significant cause of death in chronic inflammatory diseases.
- Current treatments for fibrosis are limited.
- Tenascins are matricellular proteins that regulate cell-matrix and cell-growth factor interactions.
Purpose of the Study:
- To review the role of tenascin C in fibrotic disorders.
- To highlight tenascin C as a potential biomarker and therapeutic target.
Main Methods:
- Review of existing literature on tenascin C and fibrosis.
- Analysis of data from tenascin C deficient mouse models.
- Examination of tenascin C's impact on inflammation and myofibroblast behavior.
Main Results:
- Tenascin C deficiency impacts fibrosis in mouse models.
- Tenascin C influences chronic inflammation and myofibroblast differentiation/recruitment.
- Tenascin C affects TGF-β activation and signaling.
Conclusions:
- Tenascin C is implicated in the pathogenesis of fibrotic disorders.
- Tenascin C and tenascin X are involved in fibrosis development.
- Tenascin C presents a promising target for therapeutic interventions in fibrosis.
Keywords:
MAP—kinases, Mitogen-activated protein kinasesPI3K, Phosphatidylinositol-4, 5-bisphosphate 3-kinasePKB, protein kinase Bbiomarkerextracellular matrix remodelingfibrosisinflammationtenascinMore Related Videos
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