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Plasma fibronectin in relation to surgical trauma
Scandinavian Journal of Clinical and Laboratory Investigation
|February 1, 1985
Summary
Surgical anesthesia significantly lowers plasma fibronectin (FN) levels, with most of the decrease occurring before operative trauma. Perioperative changes in fibronectin mirrored those of alpha 2-macroglobulin and orosomucoid.
Area of Science:
- Biochemistry
- Surgical Research
- Clinical Chemistry
Background:
- Plasma proteins like fibronectin (FN), alpha 2-macroglobulin, and orosomucoid are critical in physiological processes.
- Understanding their behavior during surgical procedures is essential for patient monitoring and management.
Purpose of the Study:
- To investigate the perioperative changes in plasma concentrations of fibronectin, alpha 2-macroglobulin, and orosomucoid.
- To determine if the decline in fibronectin is primarily due to anesthetic induction or surgical trauma.
Main Methods:
- Immunochemical monitoring of plasma fibronectin, alpha 2-macroglobulin, and orosomucoid levels.
- Measurements were taken in 20 patients preoperatively, during anesthesia induction, and postoperatively.
Main Results:
- Plasma fibronectin concentrations decreased by 31% ± 6% (SEM) at 2 hours post-anesthesia induction compared to preoperative values.
- A 17% ± 5% (SEM) decrease in fibronectin was observed at the start of surgery, indicating anesthesia as a primary factor.
- Perioperative changes in fibronectin were similar to those of alpha 2-macroglobulin and orosomucoid up to 2 hours postoperatively.
Conclusions:
- Anesthesia induction, rather than surgical trauma, is the main driver for the observed decrease in plasma fibronectin levels.
- Fibronectin, alpha 2-macroglobulin, and orosomucoid exhibit similar concentration changes during the perioperative period.