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Related Experiment Video

Updated: Apr 16, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
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Blood testing in chronic pain management.

Timothy R Deer1, Joshua Gunn

  • 1Center for Pain Relief, Inc, Charleston, WV; Ethos Research & Development, Fairfield, OH.

Pain Physician
|March 21, 2015
PubMed
Summary

Blood testing offers a more objective way to monitor opioid therapy compared to urine drug testing. This method provides valuable insights into patient safety and compliance for chronic pain management.

Area of Science:

  • Pharmacology
  • Clinical Chemistry
  • Pain Management

Background:

  • Traditional urine drug testing (UDT) has limitations in assessing opioid therapy.
  • Blood testing provides objective data on patient tolerance, safety, and compliance.
  • Current evidence supports blood testing in chronic pain management.

Purpose of the Study:

  • To review the evidence for blood testing in chronic pain management.
  • To introduce and discuss the role of routine blood testing.
  • To highlight the benefits of blood testing over UDT.

Main Methods:

  • Narrative review of current scientific and medical literature.
  • Focus on blood testing for opioid prescribers.
  • Discussion of novel applications in pain medicine.

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Main Results:

  • Blood testing offers valuable information not available with UDT.
  • It allows for more accurate assessment of patient compliance.
  • Blood toxicology results aid in interpreting impairment or overdose cases.

Conclusions:

  • Blood testing is a valuable tool for opioid prescribers in chronic pain management.
  • It provides objective data for patient safety and compliance.
  • Routine blood testing is anticipated to become the standard of care.