Related Experiment Video

Updated: Apr 16, 2026

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
07:32

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography

Published on: March 30, 2022

5.3K

Membrane-type matrix metalloproteinases: Their functions and regulations

Yoshifumi Itoh1

  • 1Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK.

Matrix Biology : Journal of the International Society for Matrix Biology
|March 22, 2015
PubMed

Insights

Membrane-type matrix metalloproteinases (MT-MMPs) are cell surface enzymes with unique functions. Further research into MT-MMPs promises new disease insights and therapeutic strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Membrane-type matrix metalloproteinases (MT-MMPs) are a distinct subgroup of matrix metalloproteinases (MMPs).
  • Six types of MT-MMPs exist in humans, classified as type I transmembrane or GPI-anchored.
  • Their cell surface localization grants unique functionalities impacting cellular behavior.

Purpose of the Study:

  • To review the current understanding of MT-MMP functions and regulations.
  • To highlight the significance of MT1-MMP as the most studied member.
  • To emphasize the emerging knowledge on other MT-MMPs and their potential roles.

Main Methods:

  • Literature review and synthesis of existing research on MT-MMPs.
  • Analysis of functional roles and regulatory mechanisms.
  • Comparative overview of different MT-MMP subtypes.

Main Results:

  • MT-MMPs, tethered to the plasma membrane, exhibit distinct cellular functions.
  • MT1-MMP is extensively studied, with its roles and regulations well-documented.
  • Research on other MT-MMPs (MT2, MT3, MT4, MT5, MT6) is progressively revealing their significance.

Conclusions:

  • Continued investigation of MT-MMPs is crucial for understanding disease mechanisms.
  • MT-MMPs represent promising targets for future therapeutic interventions.
  • The unique cell surface expression of MT-MMPs underpins their diverse biological impacts.
Keywords:
ECM degradationGPI-anchorMMPMT-MMPTransmembrane

More Related Videos

Detection of Functional Matrix Metalloproteinases by Zymography09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

85.2K
Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels07:39

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Published on: January 22, 2019

8.0K

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.8K
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
91.4K
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
13.7K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
10.0K
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
5.7K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.8K