[Immunoenzyme method of determining brain-specific alpha 1-globulin in glial tumors]

Specific alpha 1-globulin of the brain was assayed by an immunoenzyme technique in blood sera from cases of various brain pathologies and healthy donors. Relative elevation in brain specific alpha 1-globulin level, as compared with that in healthy subjects, was more frequent in patients with malignant glial tumors of the brain, less frequent in cases of benign glial tumors and in very few patients suffering from other brain diseases. Raised level of specific alpha 1-globulin may be caused by disorders in the blood-brain barrier or lesions in brain or tumor tissues which is peculiar to glial malignancies of the brain. The said test offers much advantage in diagnosis of glial tumors.