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Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

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Dynamic perfusion CT in brain tumors.

Timothy Pok Chi Yeung¹, Glenn Bauman², Slav Yartsev²

¹Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street N., London, Ontario, Canada N6A 5C1; London Regional Cancer Program, London Health Sciences Centre, 790 Commissioners Road East, London, ON, Canada N6A 5W9; Robarts Research Institute, The University of Western Ontario, 1151 Richmond St. N., London, Ontario, Canada N6A 5B7.

European Journal of Radiology

|March 23, 2015

Summary

This summary is machine-generated.

Dynamic perfusion CT (PCT) assesses brain tumor hemodynamics. This technique aids in tumor grading, distinguishing progression, and predicting treatment outcomes, offering valuable insights beyond traditional pathology.

Keywords:

Adiabatic Approximation of Johnson and Wilson Model Blood flow Blood volume Brain tumor Dynamic perfusion CT Permeability-surface area product

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Area of Science:

Neuroradiology
Medical Imaging
Oncology

Background:

Dynamic perfusion CT (PCT) evaluates brain tumor vascularity.
PCT parameters (blood flow, blood volume, permeability-surface area product) offer insights into tumor hemodynamics.

Purpose of the Study:

To review the fundamental principles of dynamic perfusion CT.
To discuss the diverse applications of PCT in the context of brain tumors.
To present the advantages, challenges, and potential solutions for PCT in neuro-oncology.

Main Methods:

Review of existing literature on dynamic perfusion CT for brain tumors.
Description of the biophysical principles underlying PCT measurements.
Analysis of clinical applications and outcomes associated with PCT in neuro-oncology.

Main Results:

PCT provides quantitative hemodynamic data complementary to histopathology.
PCT is utilized for brain tumor grading and differentiating high-grade gliomas.
PCT assists in distinguishing tumor progression from post-treatment effects and predicting prognosis.

Conclusions:

Dynamic perfusion CT is a valuable tool in neuro-oncology.
PCT enhances the diagnostic and prognostic capabilities for brain tumors.
Addressing current challenges can further optimize PCT's role in clinical practice.