Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

667
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
667
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

2.3K
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
2.3K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

991
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
991
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

721
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
721
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

682
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
682
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.3K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune-based personalized elimination diet for the treatment of irritable bowel syndrome: a double-blind randomized sham-controlled study.

Gastroenterology reportยท2026
Same author

Curcumin-QingDai combination for patients with active Crohn's disease: a retrospective, real-world multicenter cohort study.

Frontiers in gastroenterology (Lausanne, Switzerland)ยท2026
Same author

Curcumin-QingDai Combination for Active Ulcerative Colitis: A Cost-Effectiveness Analysis.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Researchยท2026
Same author

Glucagon-like peptide-1 receptor agonists and Wernicke encephalopathy: A pharmacovigilance study and literature review.

Clinical nutrition (Edinburgh, Scotland)ยท2026
Same author

Safety and Effectiveness of QingDai (Indigo naturalis) in Children With Mild-to-Moderate Ulcerative Colitis: A Short-Term 6-Week Open-Label Trial.

Inflammatory bowel diseasesยท2025
Same author

Acupuncture therapy in autoimmune diseases: A narrative review.

Autoimmunity reviewsยท2024

Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K

[Curcumin add-on therapy for ulcerative colitis].

Nir Salomon, Alon Lang, Dorit Gamus

    Harefuah
    |March 24, 2015
    PubMed
    Summary
    This summary is machine-generated.

    This study explores curcumin, a compound from turmeric, as a potential treatment for ulcerative colitis (UC). It presents a case report of integrating curcumin with 5-Aminosalicylic acid (5ASA) for managing this chronic inflammatory colon disease.

    More Related Videos

    Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
    06:19

    Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

    Published on: May 16, 2025

    2.4K
    Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
    08:34

    Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

    Published on: July 27, 2022

    1.4K

    Related Experiment Videos

    Last Updated: Apr 16, 2026

    Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
    06:39

    Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

    Published on: October 27, 2023

    1.6K
    Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
    06:19

    Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

    Published on: May 16, 2025

    2.4K
    Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
    08:34

    Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

    Published on: July 27, 2022

    1.4K

    Area of Science:

    • Gastroenterology
    • Natural Product Chemistry
    • Pharmacology

    Background:

    • Ulcerative colitis (UC) is a chronic inflammatory colon disease with limited treatment options.
    • Current UC treatments, often anti-inflammatory drugs, can cause adverse effects.
    • Curcumin, from turmeric, exhibits anti-inflammatory properties.

    Observation:

    • This article details a case study involving a patient with UC.
    • The patient received curcumin as an adjunct therapy alongside 5-Aminosalicylic acid (5ASA).

    Findings:

    • Curcumin's anti-inflammatory, anti-proliferative, and antibacterial properties were investigated.
    • The case report illustrates an integrative approach to managing UC.

    Implications:

    • Curcumin may offer a complementary treatment option for ulcerative colitis.
    • Further research into integrative approaches for UC management is warranted.
    • Exploring natural compounds like curcumin could lead to improved UC therapies.