[When genetics spices up a severe flare of chronic inflammatory bowel disease]

The simultaneous occurrence of pneumomediastinum, peridural emphysema, subcutaneous emphysema and pneumothorax is extremely rare. We report the case of a young man with severe chronic inflammatory bowel disease presenting with voluminous spontaneous pneumomediastinum complicated by subcutaneous emphysema as well as peridural emphysema and pneumothorax. A genetic disorder is suspected.