[18F-FPRGD2 PET/CT imaging of integrin αVβ3]

PET/CT imaging of 15F-FPRGD2 allows the visualization and quantification of integrin αVβ3 in tissues. This imaging technique was developed with the purpose of quantifying tumor angiogenesis and of assessing the efficacy of antiangiogenic treatments. However, the PET signal of 18F-FPRGD2 appears more complex as various tumor cell types, inflammatory cells and osteoclasts express the integrin αVβ3 regulating cell interactions with the extracellular matrix. This article provides data of clinical studies evaluating 18F-FPRGD2 PET/CT imaging in patients with a renal mass or a locally advanced rectal carcinoma and finally reports on the incidental discovery of 18F-FPRGD2 uptake in osteoarticular processes such as osteoarthritis.