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[Evaluation of glomerular filtration rate in 2014]
Revue Medicale De Liege
|March 24, 2015
Summary
Chronic kidney disease (CKD) is common and often detected by glomerular filtration rate (GFR) evaluation. While reference methods are underused, serum creatinine and related equations remain the primary tools for CKD assessment despite limitations.
Area of Science:
- Nephrology
- Biochemistry
- Clinical diagnostics
Context:
- Chronic kidney disease (CKD) is a prevalent global health issue.
- Glomerular filtration rate (GFR) is a key indicator for CKD detection.
- Reference methods for GFR measurement are not universally accessible or utilized.
Purpose:
- To highlight the importance of GFR evaluation in CKD detection.
- To discuss the limitations of serum creatinine as a biomarker for kidney function.
- To emphasize the continued clinical utility of creatinine-based equations for CKD assessment.
Summary:
- Serum creatinine, despite known limitations, is the most accessible marker for assessing kidney function.
- Creatinine-based equations, incorporating factors like age, gender, and ethnicity, are widely employed for CKD detection.
- Clinicians must be aware of serum creatinine's limitations when diagnosing and managing CKD.
Impact:
- Improved understanding of CKD diagnostic challenges.
- Guidance for appropriate use of creatinine-based estimations in clinical practice.
- Potential for earlier and more accurate CKD detection through awareness of biomarker limitations.
