Related Experiment Video
Updated: Apr 15, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
12.6K
Relationship between methanogenic archaea and subgingival microbial complexes in human periodontitis
H P Horz1, N Robertz2, M E Vianna3
1Division of Virology, Institute of Medical Microbiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52057 Aachen, Germany.
Anaerobe
|March 24, 2015
Summary
Methanogenic archaea may support periodontal pathogens in periodontitis. This interaction appears linked to Prevotella intermedia, a key bacterium in gum disease.
Area of Science:
- Microbiology
- Oral Health
- Periodontology
Background:
- Periodontal diseases involve complex microbial communities.
- Methanogenic archaea are increasingly recognized in oral biofilms.
- Their role in periodontitis pathogenesis requires further elucidation.
Purpose of the Study:
- To investigate the relationship between methanogenic archaea and major periodontal pathogens.
- To explore potential interactions driving periodontitis-associated bacterial consortia.
Main Methods:
- Quantitative comparison of methanogenic archaea and ten key periodontal pathogens.
- Analysis of 125 clinical samples.
- Correlation analysis to identify associations.
Main Results:
- Methanogenic archaea were quantified alongside significant periodontal pathogens.
- Correlation analysis indicated a potential supporting role for methanogenic archaea.
- This support mechanism may involve direct or indirect interactions with Prevotella intermedia.
Conclusions:
- Methanogenic archaea may contribute to the stability or growth of periodontal pathogens.
- Prevotella intermedia appears to be a crucial link in the interaction between methanogenic archaea and the periodontitis bacterial consortium.
- Further research into these interactions could reveal novel therapeutic targets for periodontitis.
Keywords:
ArchaeaMethanobrevibacter oralisPeriodontal diseasePorphyromonas gingivalisPrevotella intermediaTannerella forsythiaMore Related Videos
Related Concept Videos
01:27The Oral Microbiota
57
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
57
01:26Microbes and Methanogenesis
66
Methanogenesis is a critical microbial process in anaerobic ecosystems responsible for the biological production of methane, a potent greenhouse gas and valuable biofuel. This metabolic pathway is primarily facilitated by methanogenic archaea, which thrive in anoxic environments such as wetlands, sediments, and animal gastrointestinal tracts. The absence of oxygen in these habitats prevents aerobic respiration, thereby favoring alternative biochemical pathways for organic matter degradation.In...
66
01:30Diversity of Archaea I
908
Archaea, a domain of single-celled microorganisms, are classified into five major phyla based on genetic and biochemical characteristics: Euryarchaeota, Crenarchaeota, Thaumarchaeota, Korarchaeota, and Nanoarchaeota. Among these, the phylum Euryarchaeota is notable for its remarkable diversity in morphology, metabolism, and ecological adaptations.Morphological and Metabolic DiversityMembers of Euryarchaeota exhibit a variety of cellular shapes, including rods and cocci. Their metabolic pathways...
908
01:25Microbial Interactions: Mutualism
60
Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through...
60
01:29Overview of Archaea
1.7K
Archaea, named after the Archaean eon, represent a unique domain of life, distinct from bacteria and eukaryotes, with remarkable traits. Their cellular and molecular features, ecological adaptability, and industrial relevance highlight their importance in understanding life processes and leveraging biotechnology.Cellular and Molecular CharacteristicsA defining feature of archaea is their unique membrane composition. Archaeal membranes contain ether-linked isoprenoid lipids, which confer...
1.7K
01:28Development of the Oral Microbiota
44
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
44