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Human mesenchymal stem cells - current trends and future prospective
Imran Ullah1, Raghavendra Baregundi Subbarao1, Gyu Jin Rho1
1*Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Republic of Korea.
Bioscience Reports
|March 24, 2015
Summary
Human mesenchymal stem cells (hMSCs) are versatile adult stem cells with multi-lineage potential and immunomodulatory properties. Research highlights their diverse sources, therapeutic applications for chronic diseases, and clinical trial use.
Area of Science:
- * Regenerative Medicine
- * Stem Cell Biology
- * Immunology
Background:
- * Stem cells possess self-renewal and differentiation capabilities.
- * Human mesenchymal stem cells (hMSCs) are multipotent adult stem cells.
- * hMSCs can differentiate into various cell types and exhibit immunomodulatory functions.
Purpose of the Study:
- * To review current research on human mesenchymal stem cells (hMSCs).
- * To explore hMSC sources, characteristics, and therapeutic potential.
- * To summarize applications in chronic disease treatment and clinical trials.
Main Methods:
- * Comprehensive literature review of recent research findings.
- * Analysis of studies on hMSC isolation, characterization, and in vitro behavior.
- * Examination of data on hMSC immunomodulatory properties and clinical applications.
Main Results:
- * hMSCs are isolated from diverse tissues and express specific surface markers (CD29, CD44, CD73, CD90, CD105).
- * Long-term in vitro culturing of hMSCs is feasible without significant abnormalities.
- * hMSCs demonstrate multilineage differentiation, immunomodulation, and secretion of anti-inflammatory factors.
Conclusions:
- * hMSCs are promising for treating chronic diseases due to their regenerative and immunomodulatory capacities.
- * Further research and clinical trials are essential to fully realize the therapeutic potential of hMSCs.
- * Banking and cryopreservation strategies are crucial for hMSC availability in regenerative medicine.
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