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The Comet Cometh: Evolving Developmental Systems.

Johannes Jaeger1, Manfred Laubichler2, Werner Callebaut3

  • 1EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG), Barcelona, Spain ; Universitat Pompeu Fabra, Barcelona, Spain ; Wissenschaftskolleg zu Berlin, Berlin, Germany.

Biological Theory
|March 24, 2015
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Summary
This summary is machine-generated.

Evolutionary systems biology offers a unified framework for developmental and evolutionary biology, challenging claims that these fields are diverging. This approach uses simulation and mathematical analysis for insights into evolutionary developmental biology (EvoDevo).

Keywords:
Dynamical systems theoryEpistemologyEvolutionary developmental biology (EvoDevo)Evolutionary systems biologyNatural history of configuration spaceScientific perspectivism

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Area of Science:

  • Evolutionary developmental biology (EvoDevo)
  • Systems Biology
  • Evolutionary Systems Biology

Background:

  • A recent opinion piece suggested systems biology is separating evolutionary and developmental biology, potentially delaying their synthesis for 100 years.
  • The author identified methodological, epistemological, and social factors as reasons for this perceived divergence.

Purpose of the Study:

  • To present a contrasting view to the claim of separation between evolutionary and developmental biology.
  • To propose a research program for evolutionary systems biology as a framework for unifying EvoDevo.
  • To challenge a narrow, function-focused understanding of systems biology.

Main Methods:

  • Proposed research program based on local exploration of configuration space in evolving developmental systems.
  • Utilized reverse engineering, simulation, and mathematical analysis.
  • Examined illustrative examples of local exploration in various biological contexts.

Main Results:

  • Demonstrated the historical success of local exploration over global mapping in biological research.
  • Argued for the extension of this pragmatic inquiry to analyze developmental repertoires and evolutionary potential.
  • Showcased the utility of evolutionary systems biology in mathematical analysis.

Conclusions:

  • Evolutionary systems biology, conceived through local exploration, provides a pragmatic framework for the EvoDevo synthesis.
  • Contrasts with the view that systems biology hinders the integration of evolutionary and developmental biology.
  • Suggests a path towards reunifying evolutionary and developmental biology through an integrated systems approach.