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Related Concept Videos

Computed Tomography01:10

Computed Tomography

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Raman Spectroscopy Instrumentation: Overview01:26

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Imaging Studies III: Computed Tomography01:27

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
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Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
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Related Experiment Video

Updated: Apr 15, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
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Next-generation Raman tomography instrument for non-invasive in vivo bone imaging.

Jennifer-Lynn H Demers1, Francis W L Esmonde-White2, Karen A Esmonde-White3

  • 1Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, 03755, USA ; JLHD and FEW have made equal contributions to the manuscript.

Biomedical Optics Express
|March 24, 2015
PubMed
Summary

This study developed a novel Raman tomography system for in vivo tissue analysis. The system shows promise for diagnostic imaging and monitoring fracture healing in future studies.

Keywords:
(110.6955) Tomographic imaging(170.0110) Imaging systems(170.5660) Raman spectroscopy

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Area of Science:

  • Biomedical Engineering
  • Optical Imaging
  • Spectroscopy

Background:

  • Diffuse optical tomography and Raman spectroscopy offer in vivo tissue analysis capabilities.
  • Combining these techniques can enhance diagnostic imaging through molecular insights.

Purpose of the Study:

  • To develop and validate a novel system for Raman tomography.
  • To assess its potential for in vivo chemical and molecular measurements of tissue.

Main Methods:

  • A microCT-coupled system integrating 10 detection and 5 excitation fibers was designed.
  • Phantom studies with hydroxyapatite demonstrated linear response.
  • Cadaver and live animal models were used for optimization and validation.

Main Results:

  • Phantom measurements showed a linear response for hydroxyapatite concentrations (50-300 mg/ml).
  • System optimization was achieved using cadaver animals.
  • Initial live animal measurements validated the system's capabilities.

Conclusions:

  • The developed Raman tomography system is a promising tool for in vivo tissue analysis.
  • Further studies will focus on longitudinal measurements during fracture healing.
  • The system is being scaled for potential human measurements.