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Related Experiment Video

Updated: Apr 15, 2026

Immunostaining to Visualize Murine Enteric Nervous System Development
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Ion channel expression in the developing enteric nervous system.

Caroline S Hirst1, Jaime P P Foong2, Lincon A Stamp1

  • 1Department of Anatomy & Neuroscience, University of Melbourne, Parkville, Victoria, Australia.

Plos One
|March 24, 2015
PubMed
Summary
This summary is machine-generated.

Enteric nervous system development involves ion channels expressed by neural crest cells. However, chloride, calcium, and potassium channels are not essential for enteric nervous system cell migration or neurite growth.

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Area of Science:

  • Developmental Neuroscience
  • Ion Channel Biology
  • Gastrointestinal Physiology

Background:

  • The enteric nervous system (ENS) originates from neural crest-derived cells (ENCCs) migrating along the embryonic gut.
  • Ion channels are crucial for neuronal development and function, but their specific roles in ENS development are not fully understood.

Purpose of the Study:

  • To investigate the expression of ion channels in embryonic mouse ENCCs.
  • To determine the role of specific ion channels in ENCC migration and neurite outgrowth during ENS development.

Main Methods:

  • Utilized PCR-based arrays, RT-PCR, and immunohistochemistry to analyze ion channel gene expression in embryonic mouse ENCCs.
  • Employed pharmacological inhibitors to assess the functional impact of ion channels on ENCC migration and neuritogenesis in vitro and in cultured explants.

Main Results:

  • A broad spectrum of ion channels, including chloride, calcium, potassium, and sodium channels, were expressed by ENCCs as early as embryonic day 11.5 (E11.5).
  • Ion channel gene expression increased significantly between E11.5 and E14.5, coinciding with ENCC migration and neurite extension.
  • Pharmacological inhibition of chloride and calcium channels did not affect ENCC migration or neuritogenesis.
  • Non-selective potassium channel inhibitors impaired ENCC migration and neuritogenesis, but only at cytotoxic concentrations.

Conclusions:

  • While numerous ion channels are expressed during ENS colonization, chloride, calcium, and potassium channel activity are not required for ENCC migration or neuritogenesis.
  • The expressed ion channels are likely involved in establishing the electrical excitability of developing enteric neurons.