Related Experiment Video

Updated: Apr 15, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.2K

Leukoaraiosis with mild cognitive impairment

Mi Te, Ethan Zhao, Xingyue Zheng

    Neurological Research
    |March 24, 2015
    PubMed

    Insights

    Mild cognitive impairment (MCI) in leukoaraiosis (LA) patients (LACI) shows early memory and attention deficits, closely linked to dementia. Understanding LACI aids early diagnosis and potential treatments for this age-related cognitive decline.

    Area of Science:

    • Neurology
    • Gerontology
    • Radiology

    Background:

    • Ageing populations are experiencing increased rates of age-related cognitive impairment.
    • Mild cognitive impairment (MCI) is recognized as an early indicator of dementia.
    • Cerebral white matter lesions (WMLs), particularly leukoaraiosis (LA), are strongly associated with MCI.

    Purpose of the Study:

    • To analyze the characteristics of leukoaraiosis patients with mild cognitive impairment (LACI).
    • To explore the relationship between white matter changes and cognitive function in LA patients.
    • To identify potential avenues for early diagnosis and treatment of LACI.

    Main Methods:

    • Document analysis and consultation.
    • Review of previous diffusion tensor imaging (DTI) studies.
    • Comparative analysis of risk factors, pathogenesis, pathology, and imaging in LA and MCI.

    Main Results:

    • LA and MCI share common risk factors, pathogenesis, pathological changes, and imaging findings.
    • LACI patients exhibit early and noticeable impairments in memory, attention, and executive function.
    • Cognitive decline in LA patients correlates with the progression of leukoaraiosis.

    Conclusions:

    • LACI presents with distinct early cognitive symptoms and a strong association with dementia.
    • The shared characteristics of LA and MCI suggest a common underlying mechanism.
    • This analysis provides a foundation for the early diagnosis and potential therapeutic strategies for LACI.
    Keywords:
    DementiaLeukoaraiosis,Mild cognitive impairment,White matter lesions,

    More Related Videos

    Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment06:48

    Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

    Published on: June 25, 2019

    10.0K
    Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

    Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

    Published on: April 23, 2021

    3.5K

    Related Concept Videos

    Alzheimer's Disease: Overview01:26

    Alzheimer's Disease: Overview

    Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
    The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
    2.0K
    Dementia01:30

    Dementia

    Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
    The progression of dementia is generally gradual....
    728
    Alzheimer's Disease: Treatment01:22

    Alzheimer's Disease: Treatment

    Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
    1.3K
    Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

    Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

    Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
    802
    Visual Agnosia01:12

    Visual Agnosia

    Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
    1.8K
    Language and Cognition01:27

    Language and Cognition

    Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
    1.0K