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Formulation and in vitro evaluation of ketoprofen fast-dissolving tablets
Tansel Comoglu1, Ozge Inal1, Hajar Ben Yaacoub1
1a Faculty of Pharmacy, Department of Pharmaceutical Technology , Ankara University , Tandogan , Ankara , Turkey.
Pharmaceutical Development and Technology
|March 24, 2015
Summary
This study developed a novel taste-masking technique for bitter drugs in fast-disintegrating tablets (FDTs). Using Eudragit EPO polymer granulation effectively masked ketoprofen
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Formulation Science
Background:
- Fast-disintegrating tablets (FDTs) require effective taste masking for orally administered drugs due to disintegration in the mouth.
- Formulating high-dose bitter drugs into FDTs presents challenges in taste masking without compromising disintegration properties.
- Traditional taste-masking methods often rely on flavoring agents and sweeteners, which may not be sufficient for potent bitter compounds.
Purpose of the Study:
- To develop a novel taste-masking strategy for high-dose bitter drugs in FDTs.
- To evaluate the efficacy of Eudragit EPO polymer granulation in masking the bitter taste of ketoprofen.
- To assess the impact of Eudragit EPO and superdisintegrants on the physicochemical and disintegration properties of ketoprofen FDTs.
Main Methods:
- Ketoprofen FDTs were prepared using a two-step process: granulation with Eudragit EPO (taste-masking agent) followed by direct compression.
- Comparative formulations (F1, F2) without granulation were prepared to assess the method's effect.
- Various concentrations of superdisintegrants (crospovidone, sodium starch glycolate) were incorporated to study their influence on FDT properties.
Main Results:
- The granulation of ketoprofen with Eudragit EPO demonstrated potential for effective taste masking of the bitter drug.
- Formulations produced via granulation (F3, F4) were evaluated for their fast-disintegrating characteristics.
- The study assessed the influence of different superdisintegrant concentrations on the in vitro quality control parameters of the FDTs.
Conclusions:
- Eudragit EPO granulation offers a promising approach for taste-masking high-dose bitter drugs in FDT formulations.
- This novel method aims to improve palatability and patient compliance for orally disintegrating dosage forms.
- Further investigation into optimizing superdisintegrant levels is crucial for achieving desired FDT performance.
Keywords:
CrospovidoneEudragit EPOketoprofenorally fast-disintegrating tabletssodium starch glycolatesuperdisintegrantstaste maskingMore Related Videos
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