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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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What is the Skeletal System?01:02

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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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[Osteoporosis].

Brigitte Uebelhart, René Rizzoli

    Revue Medicale Suisse
    |March 25, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Bariatric surgery

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    Area of Science:

    • Bone metabolism and osteoporosis management.

    Background:

    • Bone events post-bariatric surgery are controversial.
    • Osteoporosis treatments like Denosumab, Romosozumab, and Odanacatib show promise.
    • Combined osteoporosis therapies (Denosumab and Teriparatide) have been explored.

    Purpose of the Study:

    • To review bone-related events following bariatric surgery.
    • To evaluate the safety and efficacy of osteoporosis pharmacotherapies.
    • To discuss ongoing debates regarding calcium supplements and cardiovascular risk.

    Main Methods:

    • Literature review of bone metabolism and osteoporosis treatments.
    • Analysis of studies on bariatric surgery outcomes.
    • Examination of clinical trial data for osteoporosis drugs.

    Main Results:

    • Denosumab is safe and effective for osteoporosis.
    • Romosozumab demonstrates anabolic potential.
    • Odanacatib reduces bone resorption and fracture risk.
    • Combined Denosumab and Teriparatide tested in osteoporosis.
    • Calcium supplements and cardiovascular risk remain debated.
    • Drug holiday post-bisphosphonates shows no increased fracture risk in moderate-risk patients.

    Conclusions:

    • Bone health after bariatric surgery requires further investigation.
    • Various pharmacologic agents offer therapeutic options for osteoporosis.
    • Long-term treatment strategies, including drug holidays, need careful consideration.