[Experience in the treatment of autoimmune male infertility in patients with category 4 chronic prostatitis]

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D G Pochernikov, E Iu Vinokurov, A I Strel'nikov

    Urologiia (Moscow, Russia : 1999)
    |March 25, 2015
    PubMed

    Insights

    Longidaza significantly reduces antisperm antibodies (ASAB) in men with chronic prostatitis, improving fertility outcomes. Treatment led to high rates of spontaneous and IVF pregnancy, supporting its use in autoimmune infertility.

    Area of Science:

    • Reproductive Immunology
    • Pharmacology
    • Urology

    Context:

    • Elevated antisperm antibodies (ASAB) are a significant factor in male infertility.
    • Chronic prostatitis can be associated with increased ASAB levels.
    • Autoimmune infertility impacts a considerable number of couples seeking conception.

    Purpose:

    • To evaluate the efficacy of Longidaza in reducing ASAB levels in patients with chronic prostatitis.
    • To assess the impact of Longidaza treatment on spontaneous and assisted reproductive technology (ART) pregnancy rates.
    • To determine the long-term effects of Longidaza on ASAB levels post-treatment.

    Summary:

    • Longidaza administration (3000 IU IM twice weekly) significantly reduced sperm surface MARIgG and MARIgA levels within one month.
    • Maximum ASAB reduction was observed after three months of treatment, with sustained low levels post-cessation in most patients.
    • Spontaneous pregnancies occurred in 10% of couples, and IVF was successful in 5% during the study period.

    Impact:

    • Longidaza demonstrates high efficacy as a pathogenetic agent for treating autoimmune infertility in men with chronic prostatitis and elevated ASAB.
    • The study supports the use of Longidaza for patients undergoing ART or attempting natural conception.
    • This therapeutic approach offers a potential solution for couples facing challenges with immunological infertility.

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