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Updated: Apr 15, 2026

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
Published on: October 7, 2021
From translational research to open technology innovation systems
1Technology Management Research Group, The Open University, Milton Keynes, UK.
This study questions linear models in translational research, proposing a quadruple helix model for health technology innovation. This enhanced framework better supports user-led and open innovation for improved healthcare advancements.
Area of Science:
- Health Technology Innovation
- Translational Research Models
- Innovation Management
Background:
- The linear model of innovation in translational research may not be the most effective for managing health technology innovation.
- Existing models can be enhanced by incorporating alternative perspectives.
Purpose of the Study:
- To evaluate the effectiveness of the linear model in translational research for health technology innovation.
- To propose an enhanced model for managing health technology innovation.
Main Methods:
- A case study approach was used to examine the development of an innovative technology within a teaching hospital.
- The case study informed the development and refinement of a health technology innovation system model.
Main Results:
- The study found that a quadruple helix model of health technology innovation, emphasizing user-led and open innovation, can refine existing translational research models.
- The quadruple helix model offers a basis for improving translational research performance.
Conclusions:
- The proposed quadruple helix model can guide alterations to current translational research models in healthcare.
- Suggestions are provided for policy and operational support of innovation activities in healthcare.
- The paper synthesizes innovation literature with a case of open innovation in the UK National Health Service.
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