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Updated: Apr 15, 2026

Visualizing Single-molecule DNA Replication with Fluorescence Microscopy
Published on: October 9, 2009
Small telescopes: detectability and the evaluation of replication results
1The Wharton School, University of Pennsylvania uws@wharton.upenn.edu.
Abstract:
This article introduces a new approach for evaluating replication results. It combines effect-size estimation with hypothesis testing, assessing the extent to which the replication results are consistent with an effect size big enough to have been detectable in the original study. The approach is demonstrated by examining replications of three well-known findings. Its benefits include the following: (a) differentiating "unsuccessful" replication attempts (i.e., studies yielding p > .05) that are too noisy from those that actively indicate the effect is undetectably different from zero, (b) "protecting" true findings from underpowered replications, and (c) arriving at intuitively compelling inferences in general and for the revisited replications in particular.
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