Related Experiment Video
Updated: Apr 15, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Protracted arthritis in a Japanese patient with familial Mediterranean fever
Kiyoshi Migita1, Sachi Hisanaga1, Yasumori Izumi1
1a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
Abstract:
The most common arthritic involvement in familial Mediterranean fever (FMF) is acute self- limiting monoarthritis which typically lasts for 72 h. Hip joint involvement is uncommon in FMF and can result either from a process specific to this disease or from a coexisting inflammatory joint disease. We describe a 37-year-old woman with FMF and right osteoarthritis secondary to congenital hip dislocation. Periodic fever with right coxalgia lasting for 6 months was treated using colchicine. Genetic analysis revealed homozygous mutation in the MEFV gene (L110P-E148Q/L110P-E148Q), confirming the FMF diagnosis. Although the clinical presentation and course of FMF arthritis are diverse, delineating these clinical patterns may help with early recognition and treatment to prevent destructive arthritis in FMF. Clinicians should consider the possibility of FMF development in unusual monoarthritis patients with recurrent febrile attacks.
Insights
Familial Mediterranean Fever (FMF) can present with unusual hip arthritis, even secondary to other conditions. Early recognition of FMF in patients with recurrent fevers and joint pain is crucial for preventing severe arthritis.
Area of Science:
- Rheumatology
- Genetics
- Internal Medicine
Background:
- Familial Mediterranean Fever (FMF) commonly causes self-limiting monoarthritis.
- Hip joint involvement in FMF is rare and can stem from FMF itself or coexisting inflammatory conditions.
Related Concept Videos
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Pericarditis I: Introduction
Pericarditis II: Clinical Features and Diagnostic Tests
Pericarditis III: Medical Management
Myocarditis II: Clinical Features and Diagnostic Tests
