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Resveratrol Ameliorates Diabetes-Induced Cardiac Dysfunction Through AT1R-ERK/p38 MAPK Signaling Pathway
Yonglin Gao1, Le Kang1, Chunmei Li2
1School of Life Sciences, Yantai University, Yantai, 264005, Shandong, People's Republic of China.
Abstract:
The present study was to determine the preventive effect of resveratrol (Res) on diabetes-induced cardiac dysfunction and the possible signaling pathway involved. Diabetes was induced in rats by injection of streptozotocin (STZ) at 45 mg/kg. The animals were randomly divided into three groups (10 rats/group): normal group, diabetes groups with or without Res (80 mg/kg) treatment. Biochemistry, cardiac function and fibrosis were detected. Moreover, pro-inflammatory cytokines were evaluated, and heart tissues were homogenized for western blot analysis to analyze the possible mechanisms. The results indicated that Res might regulate glucose and lipid metabolism, ameliorate cardiac function and fibrosis response in STZ-induced diabetic rats. The protective effects were consistent with the inhibition of inflammatory factors such as TNF-α, IL-6 and IL-1β. In addition, Res favorably shifted STZ-induced AT1R, ERK1/2 and p38 MAPK activation in rat heart. In conclusion, the results suggested that Res attenuated diabetes-induced cardiac dysfunction, and the effects were associated with attenuation inflammatory response and down-regulation of AT1R-ERK/p38 MAPK signaling pathway.
Insights
Resveratrol (Res) prevents heart dysfunction in diabetic rats by reducing inflammation and regulating key signaling pathways. This study highlights Res as a potential therapeutic for diabetic cardiomyopathy.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Diabetes mellitus is a major risk factor for cardiovascular disease.
- Diabetic cardiomyopathy is a serious complication characterized by cardiac dysfunction.
- Identifying preventive strategies is crucial for managing diabetic complications.
Purpose of the Study:
- To investigate the protective effects of resveratrol against diabetes-induced cardiac dysfunction.
- To elucidate the underlying signaling pathways involved in resveratrol's cardioprotective action.
Main Methods:
- Diabetes was induced in rats using streptozotocin (STZ).
- Resveratrol (80 mg/kg) was administered to diabetic rats.
- Cardiac function, fibrosis, glucose/lipid metabolism, and inflammatory markers were assessed.
- Western blot analysis was performed to examine signaling pathways (AT1R, ERK1/2, p38 MAPK).
Main Results:
- Resveratrol treatment improved cardiac function and reduced fibrosis in STZ-induced diabetic rats.
- Resveratrol regulated glucose and lipid metabolism.
- Resveratrol inhibited pro-inflammatory cytokines (TNF-α, IL-6, IL-1β).
- Resveratrol attenuated the activation of AT1R, ERK1/2, and p38 MAPK signaling pathways.
Conclusions:
- Resveratrol exhibits preventive effects against diabetes-induced cardiac dysfunction.
- The cardioprotective mechanisms involve the suppression of inflammatory responses.
- Resveratrol down-regulates the AT1R-ERK/p38 MAPK signaling pathway, contributing to its therapeutic benefits.
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